Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Muh-Hwa Yang
PROVIDER: E-GEOD-31910 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer research 20121130 2
Chromosomal instability (CIN) is widely considered a hallmark of cancer, but its precise roles in cancer stem cells (CSC) and malignant progression remain uncertain. BMI1 is a member of the Polycomb group of chromatin-modifier proteins that is essential for stem cell self-renewal. In human cancers, BMI1 overexpression drives stem-like properties associated with induction of epithelial-mesenchymal transition (EMT) that promotes invasion, metastasis, and poor prognosis. Here, we report that BMI1 m ...[more]