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Bmi-regulated miRNA expression pattern in head and neck cancers

ABSTRACT: The critical role of Bmi1 in promoting stem cell properties has been shown in different type of human cancers. Here, we established four stable clones to study Bmi-regulated miRNA expression patterns in head and neck caners. Bmi1-overexpressing cell lines (FaDu- Bmi1vs. FaDu-pcDNA3 cell line), and knock-down of Bmi1 cell lines (OECM1-sh-Bmi vs. OECM1-sh-Bmi1 cell lines) were established and used for analyzing miRNA expression patterms in Bmi-regulatory mechanism.

ORGANISM(S): Homo sapiens

SUBMITTER: Muh-Hwa Yang

PROVIDER: E-GEOD-31910 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer.

Chou Chun-Hung CH Yang Neng-Kai NK Liu Ting-Yun TY Tai Shyh-Kuan SK Hsu Dennis Shin-Shian DS Chen Ya-Wei YW Chen Yann-Jang YJ Chang Cheng-Chi CC Tzeng Cheng-Hwai CH Yang Muh-Hwa MH

Cancer research 20121130 2

Chromosomal instability (CIN) is widely considered a hallmark of cancer, but its precise roles in cancer stem cells (CSC) and malignant progression remain uncertain. BMI1 is a member of the Polycomb group of chromatin-modifier proteins that is essential for stem cell self-renewal. In human cancers, BMI1 overexpression drives stem-like properties associated with induction of epithelial-mesenchymal transition (EMT) that promotes invasion, metastasis, and poor prognosis. Here, we report that BMI1 m ...[more]

PMID: 23204235

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