Unknown,Transcriptomics,Genomics,Proteomics

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Profiling pancreatic islets from obese db/db and lean control db/+ mice

ABSTRACT: This program addresses the molecular basis of beta-cell failure associated with the development of type 2 diabetes in the db/db mice. Specifically, which genes are differentially expressed in pancreatic islets of the db/db mice compared to the control db/+ mice? The db/db mice islets profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the islets of db/db mice compared to the corresponding db/+ controls.

ORGANISM(S): Mus musculus

SUBMITTER: I-Ming Wang 

PROVIDER: E-GEOD-31953 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Common inflammatome gene signatures as well as disease-specific signatures were identified by analyzing 12 expression profiling data sets derived from 9 different tissues isolated from 11 rodent inflammatory disease models. The inflammatome signature significantly overlaps with known drug targets and co-expressed gene modules linked to metabolic disorders and cancer. A large proportion of genes in this signature are tightly connected in tissue-specific Bayesian networks (BNs) built from multiple  ...[more]

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