Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: lamia Guizani-Tabbane
PROVIDER: E-GEOD-31995 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PLoS neglected tropical diseases 20120821 8
We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at different times after infection with promastigotes of the protozoan parasite Leishmania major. Ingenuity Pathway Analysis revealed that the macrophage metabolic pathways including carbohydrate and lipid metabolisms were among the most altered pathways at later time points of infection. Indeed, L. major promastiogtes induced increased mRNA levels of the glucose transporter and almost all of the genes associated ...[more]