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Methotrexate activates aspects of inflammation in EA.hy 926 cells

ABSTRACT: Methotrexate (MTX) is an anti-folate drug used to treat inflammatory diseases such as rheumatoid arthritis. The changes induced by MTX were profiled within EA.hy 926 cells grown in normal (Hi) and low (Lo) folate. Several inflammatory genes were up regulated and several mitosis related genes were down regulated. Hi and Lo cells were grown to confluence and maintained in fresh medium for 24 hours prior to treatment with 0.5uM MTX for 48 hours.

ORGANISM(S): Homo sapiens

SUBMITTER: Alexander Whitehead

PROVIDER: E-GEOD-32008 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pemetrexed alters inflammatory profile in EA.hy 926 cells grown under low-folate conditions.

Project description:Pemetrexed is an antifolate drug used in the treatment of lung cancer. EA.hy 926 cells grown under low (Lo) and normal (Hi) folate conditions were treated with PMX. Microarray analysis was used to examine changes in gene expression due to PMX treatment. Hi and Lo cells were grown to confluence and maintained in fresh medium for 24 hours prior to treatment with 0.5uM PMX for 48 hours.

2012-10-03 | E-GEOD-31986 | biostudies-arrayexpress

Methotrexate activates aspects of inflammation in EA.hy 926 cells

Project description:Methotrexate (MTX) is an anti-folate drug used to treat inflammatory diseases such as rheumatoid arthritis. The changes induced by MTX were profiled within EA.hy 926 cells grown in normal (Hi) and low (Lo) folate. Several inflammatory genes were up regulated and several mitosis related genes were down regulated.

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Pemetrexed alters inflammatory profile in EA.hy 926 cells grown under low-folate conditions.

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Low paternal dietary folate alters the sperm epigenome and is associated with negative pregnancy outcomes

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2013-11-06 | E-GEOD-51819 | biostudies-arrayexpress

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Expression data from SKOV3ip1 cells treated with MORAB-003 antibody

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2014-10-31 | E-GEOD-61513 | biostudies-arrayexpress

Low paternal dietary folate alters the sperm epigenome and is associated with negative pregnancy outcomes

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2022-11-21 | PXD011046 | Pride

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