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RNA-Seq analysis of ada2M-NM-^T, nrg1M-NM-^T and cir1M-NM-^T and KN99M-NM-1 wildtype cells in capsule inducing and non-inducing conditions

ABSTRACT: To contextualize the cryptococcal Spt-Ada-Gcn5 Acetyltransferase (SAGA) member Ada2 in the capsule regulatory network, RNA-Seq was performed on wildtype, ada2M-NM-^T and two other transcription factors, nrg1M-NM-^T and cir1M-NM-^T, which like ada2M-NM-^T are also defective for capsule formation, virulence and filamentation. Mutant and wildtype cells were grown in capsule inducing and non-inducing conditions for 90 minutes and transcriptional profiling was performed by RNA-Seq analysis.

ORGANISM(S): Cryptococcus neoformans

SUBMITTER: Brian Haynes

PROVIDER: E-GEOD-32049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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