Expression data from breast cancer FNA and surgical specimens from patients
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: TAKAYUKI IWAMOTO
PROVIDER: E-GEOD-32072 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression, molecular class changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer.
Gonzalez-Angulo Ana M AM Iwamoto Takayuki T Liu Shuying S Chen Huiqin H Do Kim-Anh KA Hortobagyi Gabriel N GN Mills Gordon B GB Meric-Bernstam Funda F Symmans W Fraser WF Pusztai Lajos L
Clinical cancer research : an official journal of the American Association for Cancer Research 20120110 4
<h4>Purpose</h4>To examine gene expression differences between pre- and post-neoadjuvant systemic therapy (NST) specimens of breast cancers and identify biologic changers that may lead to new therapeutic insights.<h4>Methods</h4>Gene expression data from prechemotherapy fine needle aspiration specimens were compared with resected residual cancers in 21 patients after 4 to 6 months of NST. We removed stroma-associated genes to minimize confounding effects. PAM50 was used to assign molecular class ...[more]
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