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DNA methylation in peripheral blood from individuals with Crohns' disease or ulcerative colitis and normal controls

ABSTRACT: Genome wide DNA methylation profiling of Crohn's disease, ulcerative colitis, and normal peripheral blood samples. The Illumina Infinium HumanMethylation450 BeadChip v1.1 was used to obtain DNA methylation profiles across 482,421 CpGs in peripheral blood samples. Samples came from 17 Crohn's disease affected, 11 ulcerative colitis affected, and 20 normal individuals. Within these samples were three twin sets discordant for Crohn's disease and three twin sets discordant for ulcerative colitis. Bisulfite converted DNA from the 48 samples were hybridized to the Illumina Infinium HumanMethylation450 BeadChip v1.1

ORGANISM(S): Homo sapiens

SUBMITTER: R. Harris 

PROVIDER: E-GEOD-32148 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases.

Harris R Alan RA   Nagy-Szakal Dorottya D   Pedersen Natalia N   Opekun Antone A   Bronsky Jiri J   Munkholm Pia P   Jespersgaard Cathrine C   Andersen PaalSkytt P   Melegh Bela B   Ferry George G   Jess Tine T   Kellermayer Richard R  

Inflammatory bowel diseases 20120329 12

<h4>Background</h4>Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in  ...[more]

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