Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Lasse Folkersen
PROVIDER: E-GEOD-32325 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Iglesias Maria Jesus MJ Reilly Sarah-Jayne SJ Emanuelsson Olof O Sennblad Bengt B Pirmoradian Najafabadi Mohammad M Folkersen Lasse L Mälarstig Anders A Lagergren Jens J Eriksson Per P Hamsten Anders A Odeberg Jacob J
PloS one 20120227 2
Macrophages play a critical role in innate immunity, and the expression of early response genes orchestrate much of the initial response of the immune system. Macrophages undergo extensive transcriptional reprogramming in response to inflammatory stimuli such as Lipopolysaccharide (LPS).To identify gene transcription regulation patterns involved in early innate immune responses, we used two genome-wide approaches--gene expression profiling and chromatin immunoprecipitation-sequencing (ChIP-seq) ...[more]