Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Guido Hooiveld
PROVIDER: E-GEOD-32357 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Timmers Silvie S Konings Ellen E Bilet Lena L Houtkooper Riekelt H RH van de Weijer Tineke T Goossens Gijs H GH Hoeks Joris J van der Krieken Sophie S Ryu Dongryeol D Kersten Sander S Moonen-Kornips Esther E Hesselink Matthijs K C MKC Kunz Iris I Schrauwen-Hinderling Vera B VB Blaak Ellen E Auwerx Johan J Schrauwen Patrick P
Cell metabolism 20111101 5
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthas ...[more]