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Innate response activator B cells are sentinels that guard against polymicrobial sepsis

ABSTRACT: Innate immunity is fundamental to recognition and clearance of bacterial infection. The relevant cells and molecules that orchestrate an effective response, however, remain incompletely understood. Here we describe a previously unknown population of B cells, which we have named innate response activator (IRA) B cells that recognize bacteria directly through TLR-4-MyD88 and protect against polymicrobial sepsis. IRA-B cells have a unique IgM high CD23 low CD43 + CD93+ GM-CSF+ signature, develop and diverge from B1a B cells, require BAFFR, and adhere to tissue via VLA-4 and LFA-1. B cell subsets are sorted from the spleen and peritoneum of C57BL/6 mice that were given intraperitoneal injections of LPS once daily for four days.

ORGANISM(S): Mus musculus

SUBMITTER: Martin Etzrodt

PROVIDER: E-GEOD-32372 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Innate response activator B cells protect against microbial sepsis.

Rauch Philipp J PJ Chudnovskiy Aleksey A Robbins Clinton S CS Weber Georg F GF Etzrodt Martin M Hilgendorf Ingo I Tiglao Elizabeth E Figueiredo Jose-Luiz JL Iwamoto Yoshiko Y Theurl Igor I Gorbatov Rostic R Waring Michael T MT Chicoine Adam T AT Mouded Majd M Pittet Mikael J MJ Nahrendorf Matthias M Weissleder Ralph R Swirski Filip K FK

Science (New York, N.Y.) 20120112 6068

Recognition and clearance of a bacterial infection are a fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytok ...[more]

PMID: 22245738

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Innate response activator B cells are sentinels that guard against polymicrobial sepsis

Publications

Innate response activator B cells protect against microbial sepsis.

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