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Integrated analysis of the transcriptome-lipidome reveals the interactions of inositol-choline and SNF1 in controlling lipid biosynthesis

ABSTRACT: Characterize the transcriptional response to inositol-choline and snf1 We used microarrays to capture the global responses of inositol-choline concentration and snf deletion in Carbon and Nitrogen limited growth

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Intawat Nookaew

PROVIDER: E-GEOD-32418 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated analysis of transcriptome and lipid profiling reveals the co-influences of inositol-choline and Snf1 in controlling lipid biosynthesis in yeast.

Chumnanpuen Pramote P Zhang Jie J Nookaew Intawat I Nielsen Jens J

Molecular genetics and genomics : MGG 20120524 7

In the yeast Saccharomyces cerevisiae many genes involved in lipid biosynthesis are transcriptionally controlled by inositol-choline and the protein kinase Snf1. Here we undertook a global study on how inositol-choline and Snf1 interact in controlling lipid metabolism in yeast. Using both a reference strain (CEN.PK113-7D) and a snf1Δ strain cultured at different nutrient limitations (carbon and nitrogen), at a fixed specific growth rate of 0.1 h(-1), and at different inositol choline concentrati ...[more]

PMID: 22622761

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