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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human hemopoietic progenitors and myeloid differentiated cells

ABSTRACT: Differential gene expression profiling of human hemopoietic progenitors and myeloid differentiated cells Experiment Overall Design: We assessed the gene expression in Lin+CD34+, CD14+, CD16+ and CD16- cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Rossella Manfredini

PROVIDER: E-GEOD-3242 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Eosinophils, but not neutrophils, exhibit an efficient DNA repair machinery and high nucleolar activity.

Salati Simona S Bianchi Elisa E Zini Roberta R Tenedini Elena E Quaglino Daniela D Manfredini Rossella R Ferrari Sergio S

Haematologica 20071001 10

<h4>Background and objectives</h4>Traditionally eosinophils have been considered terminally differentiated cells that play a role in host protection against parasites. However, there is some evidence showing that eosinophils are, in fact, multifunctional leukocytes involved in inflammatory responses, as well as in tissue homeostasis. We characterized the transcriptome profile of human eosinophils, and, for the purpose of comparison, the transcriptome profile of neutrophils, monocytes and hematop ...[more]

PMID: 17768116

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