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Expression data from BMDC cells with or without Sendai virus infection

ABSTRACT: Innate immunity is the first line of defense against viral and microbial pathogens. BMDC is critical for innate immunity. To investigate the complicated net signaling after virus invasion, we did a cDNA microarray analysis of BMDC with or without Sendai Virus infection. We used microarrays to find proteins that upregulated by Sendai Virus infection and investigated if these proteins had functions in regulating Sendai Virus induced signaling pathway. BMDC cells are seperated from C57BL6 mice, infected with Sendai Virus or not,cultured and harveseted for RNA extraction and hybridization on Affymetrix microarrays

ORGANISM(S): Mus musculus

SUBMITTER: Yuan Zhang 

PROVIDER: E-GEOD-32499 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7.

Hu Yu Y   Wang Jie J   Yang Bo B   Zheng Nuoyan N   Qin Meiling M   Ji Yongyong Y   Lin Guomei G   Tian Lin L   Wu Xiaodong X   Wu Li L   Sun Bing B  

Journal of immunology (Baltimore, Md. : 1950) 20111116 12

IRF7 is known as the master regulator in virus-triggered induction of type I IFNs (IFN-I). In this study, we identify GBP4 virus-induced protein interacting with IRF7 as a negative regulator for IFN-I response. Overexpression of GBP4 inhibits virus-triggered activation of IRF7-dependent signaling, but has no effect on NF-κB signaling, whereas the knockdown of GBP4 has opposite effects. Furthermore, the supernatant from Sendai virus-infected cells in which GBP4 have been silenced inhibits the rep  ...[more]

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