Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: wang xianming
PROVIDER: E-GEOD-32527 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Wen W Wang Xianming X Fan Wenxia W Zhao Ping P Chan Yau-Chi YC Chen Shen S Zhang Shiqiang S Guo Xiangpeng X Zhang Ya Y Li Yanhua Y Cai Jinglei J Qin Dajiang D Li Xingyan X Yang Jiayin J Peng Tianran T Zychlinski Daniela D Hoffmann Dirk D Zhang Ruosi R Deng Kang K Ng Kwong-Man KM Menten Bjorn B Zhong Mei M Wu Jiayan J Li Zhiyuan Z Chen Yonglong Y Schambach Axel A Tse Hung-Fat HF Pei Duanqing D Esteban Miguel A MA
Human molecular genetics 20110923 1
Many human diseases share a developmental origin that manifests during childhood or maturity. Aneuploid syndromes are caused by supernumerary or reduced number of chromosomes and represent an extreme example of developmental disease, as they have devastating consequences before and after birth. Investigating how alterations in gene dosage drive these conditions is relevant because it might help treat some clinical aspects. It may also provide explanations as to how quantitative differences in ge ...[more]