Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide mapping of Sox6 binding sites in mouse fetal myotubes


ABSTRACT: In order to understand how Sox6 coordinately regulates the transcription of multiple fiber type specific genes during muscle development, we have performed ChIP-seq analyses to identify Sox6 target genes as well as RNA polymerase II (Pol II) binding sites in mouse fetal myotubes. Examination of Sox6 and Pol II binding sites in mouse fetal primary myotubes

ORGANISM(S): Mus musculus

SUBMITTER: Chungil An 

PROVIDER: E-GEOD-32627 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.

An Chung-Il CI   Dong Yao Y   Hagiwara Nobuko N  

BMC developmental biology 20111010


<h4>Background</h4>Sox6 is a multi-faceted transcription factor involved in the terminal differentiation of many different cell types in vertebrates. It has been suggested that in mice as well as in zebrafish Sox6 plays a role in the terminal differentiation of skeletal muscle by suppressing transcription of slow fiber specific genes. In order to understand how Sox6 coordinately regulates the transcription of multiple fiber type specific genes during muscle development, we have performed ChIP-se  ...[more]

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