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MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

ABSTRACT: We compared the aorta of 6-weeks-old mice (young) with 18-months-old mice (old). Using the publicly available tools Sylamer and DIANA-mirExTra, we identified an enrichment for miR-29 binding sites in the 3'UTR of genes downregulated in the aged aortas. We subsequently showed that inhibition of miR-29 in aged mice prevented dilation of the aorta. aortas of 6 week old and 18 month old mice

ORGANISM(S): Mus musculus

SUBMITTER: Reinier Boon

PROVIDER: E-GEOD-32937 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA-29 in aortic dilation: implications for aneurysm formation.

Boon Reinier A RA Seeger Timon T Heydt Susanne S Fischer Ariane A Hergenreider Eduard E Horrevoets Anton J G AJ Vinciguerra Manlio M Rosenthal Nadia N Sciacca Sergio S Pilato Michele M van Heijningen Paula P Essers Jeroen J Brandes Ralf P RP Zeiher Andreas M AM Dimmeler Stefanie S

Circulation research 20110908 10

<h4>Rationale</h4>Aging represents a major risk factor for coronary artery disease and aortic aneurysm formation. MicroRNAs (miRs) have emerged as key regulators of biological processes, but their role in age-associated vascular pathologies is unknown.<h4>Objective</h4>We aim to identify miRs in the vasculature that are regulated by age and play a role in age-induced vascular pathologies.<h4>Methods and results</h4>Expression profiling of aortic tissue of young versus old mice identified several ...[more]

PMID: 21903938

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Project description:We compared the aorta of 6-weeks-old mice (young) with 18-months-old mice (old). Using the publicly available tools Sylamer and DIANA-mirExTra, we identified an enrichment for miR-29 binding sites in the 3'UTR of genes downregulated in the aged aortas. We subsequently showed that inhibition of miR-29 in aged mice prevented dilation of the aorta.

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