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Identification of novel candidate oncogenes in chromosomal region 17p11.2-p12 in human osteosarcoma

ABSTRACT: in 25% - 30% of all OS cases the chromosome region 17p11.2-p12 is aberrant. Using SNP array in conjunction with expression microarrays we try to identify genes which can be classified as oncogens or are in someway benificial to the survival of the tumor. To identify minimal significant amplified region(s) that is(are) aberrant in osteosarcoma tumorigenesis, with a special emphasis on but not limitied to chromosome region 17p11.2-p12

ORGANISM(S): Homo sapiens

SUBMITTER: Joeri Both

PROVIDER: E-GEOD-32964 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma.

Both Joeri J Wu Thijs T Bras Johannes J Schaap Gerard R GR Baas Frank F Hulsebos Theo J M TJ

PloS one 20120126 1

Osteosarcoma is the most common primary malignancy of bone. The tumours are characterized by high genomic instability, including the occurrence of multiple regions of amplifications and deletions. Chromosome region 17p11.2-p12 is amplified in about 25% of cases. In previous studies, COPS3 and PMP22 have been identified as candidate oncogenes in this region. Considering the complexity and variation of the amplification profiles for this segment, the involvement of additional causative oncogenes i ...[more]

PMID: 22292074

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