Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Louis Staudt
PROVIDER: E-GEOD-33012 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yang Yibin Y Shaffer Arthur L AL Emre N C Tolga NC Ceribelli Michele M Zhang Meili M Wright George G Xiao Wenming W Powell John J Platig John J Kohlhammer Holger H Young Ryan M RM Zhao Hong H Yang Yandan Y Xu Weihong W Buggy Joseph J JJ Balasubramanian Sriram S Mathews Lesley A LA Shinn Paul P Guha Rajarshi R Ferrer Marc M Thomas Craig C Waldmann Thomas A TA Staudt Louis M LM
Cancer cell 20120601 6
Knowledge of oncogenic mutations can inspire therapeutic strategies that are synthetically lethal, affecting cancer cells while sparing normal cells. Lenalidomide is an active agent in the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), but its mechanism of action is unknown. Lenalidomide kills ABC DLBCL cells by augmenting interferon β (IFNβ) production, owing to the oncogenic MYD88 mutations in these lymphomas. In a cereblon-dependent fashion, lenalidomide downreg ...[more]