Integrated analysis of omics profiles
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hogune Im
PROVIDER: E-GEOD-33029 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Personal omics profiling reveals dynamic molecular and medical phenotypes.
Chen Rui R Mias George I GI Li-Pook-Than Jennifer J Jiang Lihua L Lam Hugo Y K HY Chen Rong R Miriami Elana E Karczewski Konrad J KJ Karczewski Konrad J KJ Hariharan Manoj M Dewey Frederick E FE Cheng Yong Y Clark Michael J MJ Im Hogune H Habegger Lukas L Balasubramanian Suganthi S O'Huallachain Maeve M Dudley Joel T JT Hillenmeyer Sara S Haraksingh Rajini R Sharon Donald D Euskirchen Ghia G Lacroute Phil P Bettinger Keith K Boyle Alan P AP Kasowski Maya M Grubert Fabian F Seki Scott S Garcia Marco M Whirl-Carrillo Michelle M Gallardo Mercedes M Blasco Maria A MA Greenberg Peter L PL Snyder Phyllis P Klein Teri E TE Altman Russ B RB Butte Atul J AJ Ashley Euan A EA Gerstein Mark M Nadeau Kari C KC Tang Hua H Snyder Michael M
Cell 20120301 6
Personalized medicine is expected to benefit from combining genomic information with regular monitoring of physiological states by multiple high-throughput methods. Here, we present an integrative personal omics profile (iPOP), an analysis that combines genomic, transcriptomic, proteomic, metabolomic, and autoantibody profiles from a single individual over a 14 month period. Our iPOP analysis revealed various medical risks, including type 2 diabetes. It also uncovered extensive, dynamic changes ...[more]
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