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Meta-analysis of Clear Cell Renal Cell Carcinoma Gene Expression Defines a Variant Subgroup and Identifies Gender Influences on Tumor Biology

ABSTRACT: Clear cell renal cell carcinoma comprises two dominant subtypes, ccA and ccB, with gender disparity providing additional disease information. A third minor subgroup has distinct expression profiles consistent with von Hippel-Lindau wild type status and displays variant histology features. 44 new tumor samples and six large, publicly available, ccRCC gene expression databases were identified that cumulatively provided data for 480 tumors for metaanalysis via meta-array compilation.

ORGANISM(S): Homo sapiens

SUBMITTER: Kimryn Rathmell

PROVIDER: E-GEOD-33093 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology.

Brannon A Rose AR Haake Scott M SM Hacker Kathryn E KE Pruthi Raj S RS Wallen Eric M EM Nielsen Matthew E ME Rathmell W Kimryn WK

European urology 20111018 2

<h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) displays molecular and histologic heterogeneity. Previously described subsets of this disease, ccA and ccB, were defined based on multigene expression profiles, but it is unclear whether these subgroupings reflect the full spectrum of disease or how these molecular subtypes relate to histologic descriptions or gender.<h4>Objective</h4>Determine whether additional subtypes of ccRCC exist and whether these subtypes are related to von Hippe ...[more]

PMID: 22030119

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