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Expression data from livers in wildtype and Sox17+/-mice at 17dpc

ABSTRACT: The onset of the liver inflamentation in the Sox17+/- embryos. The expression of Cxcl10, Cxcl2, Cxcl1 and stress-induced heat shock protein Hspa1a and Hspa1b were elevated in Sox17+/- livers at 17dpc, as compared with the wildtype livers. Total RNAs from liver tissues of wildtype and Sox17+/- mice at 17dpc were subjected to microarray analyses. Two biological replicates of each genotype were analyzed.

ORGANISM(S): Mus musculus

SUBMITTER: Mami Uemura

PROVIDER: E-GEOD-33106 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice.

Uemura Mami M Ozawa Aisa A Nagata Takumi T Kurasawa Kaoruko K Tsunekawa Naoki N Nobuhisa Ikuo I Taga Tetsuya T Hara Kenshiro K Kudo Akihiko A Kawakami Hayato H Saijoh Yukio Y Kurohmaru Masamichi M Kanai-Azuma Masami M Kanai Yoshiakira Y

Development (Cambridge, England) 20130201 3

Congenital biliary atresia is an incurable disease of newborn infants, of unknown genetic causes, that results in congenital deformation of the gallbladder and biliary duct system. Here, we show that during mouse organogenesis, insufficient SOX17 expression in the gallbladder and bile duct epithelia results in congenital biliary atresia and subsequent acute 'embryonic hepatitis', leading to perinatal death in ~95% of the Sox17 heterozygote neonates in C57BL/6 (B6) background mice. During gallbla ...[more]

PMID: 23293295

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