Unknown,Transcriptomics,Genomics,Proteomics

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Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE32362: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Illumina HumanMethylation450 BeadChip) GSE33129: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Illumina HiSeq2000 sequencing) Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: michael bocker 

PROVIDER: E-GEOD-33130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster.

Bocker Michael T MT   Tuorto Francesca F   Raddatz Günter G   Musch Tanja T   Yang Feng-Chun FC   Xu Mingjiang M   Lyko Frank F   Breiling Achim A  

Nature communications 20120508


Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we use the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modification patterns during retinoic acid-induced differentiation. We find the inactive cluster to be marked by defined patterns of 5-methylcytosine (5mC). Upon the induction of differentiation, the active  ...[more]

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