Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: michael bocker
PROVIDER: E-GEOD-33130 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bocker Michael T MT Tuorto Francesca F Raddatz Günter G Musch Tanja T Yang Feng-Chun FC Xu Mingjiang M Lyko Frank F Breiling Achim A
Nature communications 20120508
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we use the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modification patterns during retinoic acid-induced differentiation. We find the inactive cluster to be marked by defined patterns of 5-methylcytosine (5mC). Upon the induction of differentiation, the active ...[more]