Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Oh Kyu Yoon
PROVIDER: E-GEOD-33154 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PLoS genetics 20120816 8
Gene expression varies widely between individuals of a population, and regulatory change can underlie phenotypes of evolutionary and biomedical relevance. A key question in the field is how DNA sequence variants impact gene expression, with most mechanistic studies to date focused on the effects of genetic change on regulatory regions upstream of protein-coding sequence. By contrast, the role of RNA 3'-end processing in regulatory variation remains largely unknown, owing in part to the challenge ...[more]