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Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression signatures following nerve injury in a rat model (0h-9h)

ABSTRACT: We used microarrays to distinguish the gene expression differences among different time points after injury. We generated proximal sciatic nerve (SN) tissues (0.5cm) at 0h, 0.5h, 1h, 3h, 6h and 9h after sciatic nerve resection.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Guohui Ding

PROVIDER: E-GEOD-33175 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene network revealed involvements of Birc2, Birc3 and Tnfrsf1a in anti-apoptosis of injured peripheral nerves.

Wang Yongjun Y Tang Xin X Yu Bin B Gu Yun Y Yuan Ying Y Yao Dengbing D Ding Fei F Gu Xiaosong X

PloS one 20120917 9

Crush injury or axotomy of peripheral nerves results in the rapid production of the inflammatory cytokines, which were confirmed in various models, to some extent, to be noxious to the myelin sheath or Schwann cells (SCs). TNF-α is one of the primary initiators of the inflammatory cascade and exerts pleiotropic functions in the physiological conditions by binding to its receptors, type I (TNFRI) and type II (TNFRII). The pathway molecules TNFRI, Birc2 and Birc3 play key roles during the activati ...[more]

PMID: 23028454

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