Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Gilad Fuchs
PROVIDER: E-GEOD-33214 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Molecular cell 20120601 5
Embryonic stem cells (ESCs) maintain high genomic plasticity, which is essential for their capacity to enter diverse differentiation pathways. Posttranscriptional modifications of chromatin histones play a pivotal role in maintaining this plasticity. We now report that one such modification, monoubiquitylation of histone H2B on lysine 120 (H2Bub1), catalyzed by the E3 ligase RNF20, increases during ESC differentiation and is required for efficient execution of this process. This increase is part ...[more]