Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Maciej Paszkowski-Rogacz
PROVIDER: E-GEOD-33280 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ross Katharina K Sedello Anna K AK Todd Gabriele Putz GP Paszkowski-Rogacz Maciej M Bird Alexander W AW Ding Li L Grinenko Tatyana T Behrens Kira K Hubner Nina N Mann Matthias M Waskow Claudia C Stocking Carol C Buchholz Frank F
Blood 20120312 18
The transcription factor runt-related transcription factor 1 (Runx1) is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation of hematopoietic stem and progenitor cells. However, how Runx1 orchestrates self-renewal and lineage choices in combination with other factors is not well understood. In the presen ...[more]