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Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics

ABSTRACT: This study aimed at characterizing the effect of the innate immune agonist, dsRNA, on ovarian cancer cell lines and ascites-derived ovarian cancer cells. DsRNA stimulation revealed two sub-populations of ovarian cancer cells, dsRNA sensitive and dsRNA resistant, that could be categorized based upon dsRNA-induced dsRNA receptor expression. Human ovarian cancer cell lines were treated with pI:pC and compared against untreated cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Jessica Bell

PROVIDER: E-GEOD-33342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics

Project description:This study aimed at characterizing the effect of the innate immune agonist, dsRNA, on ovarian cancer cell lines and ascites-derived ovarian cancer cells. DsRNA stimulation revealed two sub-populations of ovarian cancer cells, dsRNA sensitive and dsRNA resistant, that could be categorized based upon dsRNA-induced dsRNA receptor expression.

2012-04-29 | GSE33342 | GEO

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2012-06-22 | E-GEOD-38889 | biostudies-arrayexpress

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