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Expression data from phenotypically discordant monozygotic twin lymphoblasts

ABSTRACT: Human intelligence demonstrates one of the highest heritabilities among human quantitative traits. Phenotypically discordant monozygotic twins provide a way to identify loci responsible for normal-range intelligence. We conducted array-based genome-wide gene expression analysis aiming to identify genes displaying significant difference among monozygotic twin pairs manifesting between-co-twins IQ differences. Total RNA was isolated from B-lymphoblastoid cell lines and applied to Affymetirx arrays after reverse transcription. 17 twin pairs (34 subjects) were recruited in this study.

ORGANISM(S): Homo sapiens

SUBMITTER: Chihchieh Yu

PROVIDER: E-GEOD-33476 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from phenotypically discordant monozygotic twin lymphoblasts

Project description:Human intelligence demonstrates one of the highest heritabilities among human quantitative traits. Phenotypically discordant monozygotic twins provide a way to identify loci responsible for normal-range intelligence. We conducted array-based genome-wide gene expression analysis aiming to identify genes displaying significant difference among monozygotic twin pairs manifesting between-co-twins IQ differences.

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Genome-wide DNA methylation and gene expression analyses of monozygotic twin discordant for intelligence levels

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