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Chemokine expressions in breast cancer patients

ABSTRACT: Our aim was to evaluate the expression of chemokines in breast cancers before treatment to identify a molecular signature that could distinguish between women with or without cancer. We identified a panel of chemokines clearly deregulated in breast cancer that could be further investigated for prospective novel markers or therapeutically approaches. Samples for gene expression were obtained during surgical resection and after macroscopic pathological assessment. Laser-capture microdissection was used to select and procure only the desired cell types (malignant groups of cells or normal mammary acini), under direct microscopic visualization Chemokine expression profiles using cDNA microarray was evaluated on homogenous, laser-capture microdissected breast cancer specimens before treatment.

ORGANISM(S): Homo sapiens

SUBMITTER: Diana Narita

PROVIDER: E-GEOD-33487 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chemokine expressions in breast cancer patients

Project description:Our aim was to evaluate the expression of chemokines in breast cancers before treatment to identify a molecular signature that could distinguish between women with or without cancer. We identified a panel of chemokines clearly deregulated in breast cancer that could be further investigated for prospective novel markers or therapeutically approaches. Samples for gene expression were obtained during surgical resection and after macroscopic pathological assessment. Laser-capture microdissection was used to select and procure only the desired cell types (malignant groups of cells or normal mammary acini), under direct microscopic visualization

2011-11-05 | GSE33487 | GEO

COX-2 overexpression in a conditional KrasG12D mouse model

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2022-07-12 | PXD034078 | Pride

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Tumor-associated stroma derived from primary clinical breast cancer samples

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Project description:Tumor epithelium and surrounding stromal cells were isolated using laser capture microdissection of human breast cancer to examine differences in gene expression based on tissue types from inflammatory and non-inflammatory breast cancer Keywords: LCM

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