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TaqMan Peripheral blood mononuclear cell miRNA profiles of HIV-1-infected elite suppressors, viremic patients, and uninfected control donors

ABSTRACT: This study used TaqMan low-density arrays to identify and quantitate circulating cellular miRNAs during HIV-1 elite suppression, active HIV-1 replication, and uninfected status. Blood samples were from six uninfected controls, six HIV-1 elite suppressors with undetectable viral load, and six viremic HIV-1-infected patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Kenneth Witwer

PROVIDER: E-GEOD-33492 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients.

Witwer Kenneth W KW Watson Andria K AK Blankson Joel N JN Clements Janice E JE

Retrovirology 20120112

<h4>Background</h4>HIV-1-infected elite controllers or suppressors (ES) maintain undetectable viral loads (< 50 copies/mL) without antiretroviral therapy. The mechanisms of suppression are incompletely understood. Modulation of HIV-1 replication by miRNAs has been reported, but the role of small RNAs in ES is unknown. Using samples from a well-characterized ES cohort, untreated viremic patients, and uninfected controls, we explored the PBMC miRNA profile and probed the relationships of miRNA exp ...[more]

PMID: 22240256

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