Unknown,Transcriptomics,Genomics,Proteomics

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In vivo and transcriptome-wide identification of RNA-binding protein target sites


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE33569: In vivo and transcriptome-wide identification of RNA-binding protein target sites [PAR-CLIP] GSE33573: In vivo and transcriptome-wide identification of RNA-binding protein target sites [RNA-Seq] Refer to individual Series

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Dominic Gruen 

PROVIDER: E-GEOD-33543 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

In vivo and transcriptome-wide identification of RNA binding protein target sites.

Jungkamp Anna-Carina AC   Stoeckius Marlon M   Mecenas Desirea D   Grün Dominic D   Mastrobuoni Guido G   Kempa Stefan S   Rajewsky Nikolaus N  

Molecular cell 20111201 5


Animal mRNAs are regulated by hundreds of RNA binding proteins (RBPs). The identification of RBP targets is crucial for understanding their function. A recent method, PAR-CLIP, uses photoreactive nucleosides to crosslink RBPs to target RNAs in cells prior to immunoprecipitation. Here, we establish iPAR-CLIP (in vivo PAR-CLIP) to determine, at nucleotide resolution, transcriptome-wide binding sites of GLD-1, a conserved, germline-specific translational repressor in C. elegans. We identified 439 r  ...[more]

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