Hen1 analysis in zebrafish
Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Eugene Berezikov
PROVIDER: E-GEOD-33582 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hen1 is required for oocyte development and piRNA stability in zebrafish.
Kamminga Leonie M LM Luteijn Maartje J MJ den Broeder Marjo J MJ Redl Stefan S Kaaij Lucas J T LJ Roovers Elke F EF Ladurner Peter P Berezikov Eugene E Ketting René F RF
The EMBO journal 20100921 21
Piwi-interacting RNAs (piRNAs) are germ line-specific small RNA molecules that have a function in genome defence and germ cell development. They associate with a specific class of Argonaute proteins, named Piwi, and function through an RNA interference-like mechanism. piRNAs carry a 2'-O-methyl modification at their 3' end, which is added by the Hen1 enzyme. We show that zebrafish hen1 is specifically expressed in germ cells and is essential for maintaining a female germ line, whereas it is disp ...[more]
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