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Expression data of IL-18 generated murine NK cells

ABSTRACT: We analyzed gene expression profiles of IL-18 generated murine NK cells in comparison to unstimulated, freshly isolated splenic NK cells. We identified a set of 1414 Affymetrix probe sets showing significant misregulation (Welch's T-test, p<0.05; Benjamini-Hochberg FDR corrected). IL-18 generated as well as unstimulated NK cells were isolated in three independent preparations and used for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Rene Deenen

PROVIDER: E-GEOD-33627 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Immunoregulatory natural killer cells suppress autoimmunity by down-regulating antigen-specific CD8+ T cells in mice.

Ehlers Margret M Papewalis Claudia C Stenzel Wiebke W Jacobs Benedikt B Meyer Klaus L KL Deenen René R Willenberg Holger S HS Schinner Sven S Thiel Annette A Scherbaum Werner A WA Ullrich Evelyn E Zitvogel Laurence L Schott Matthias M

Endocrinology 20120625 9

Natural killer (NK) cells belong to the innate immune system. Besides their role in antitumor immunity, NK cells also regulate the activity of other cells of the immune system, including dendritic cells, macrophages, and T cells, and may, therefore, be involved in autoimmune processes. The aim of the present study was to clarify the role of NK cells within this context. Using two mouse models for type 1 diabetes mellitus, a new subset of NK cells with regulatory function was identified. These ce ...[more]

PMID: 22733969

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2014-02-01 | E-GEOD-43958 | biostudies-arrayexpress

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