Gene expression from healthy male and female porcine aortic valve leaflets

ABSTRACT: Calcific aortic valvular disease (CAVD) is characterized by sclerosis of the aortic valve leaflets and recent clinical studies have linked several other risk factors to this disease, including male sex. In this study we examined potential sex-related differences in gene expression profiles between porcine male and female valvular interstitial cells (VICs) to explore possible differences in CAVD propensity on the cellular level. RNA samples from three male and three female healthy porcine aortic valve leaflets (denuded of endothelial cells) were isolated, processed, and hybridized to AffymetrixM-BM-. GeneChip Porcine Genome microarrays according to manufacturerM-bM-^@M-^Ys instructions. Mean expression values of each probe set in the male samples were compared with those in the female sam

ORGANISM(S): Sus scrofa

SUBMITTER: Kristyn Masters 

PROVIDER: E-GEOD-33654 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress