Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Effect of erythropoietin on cerebral ischemia-induced changes in gene expression in rats

ABSTRACT: Analysis of the gene expression profile in the cerebral cortex of rats 2h or 6h after middle cerebral artery occlusion with or without a single erythropoietin treatment 6 conditions with each 3 replicates, hybridized with 1 color.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Joke Allemeersch

PROVIDER: E-GEOD-33725 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke.

Mengozzi Manuela M Cervellini Ilaria I Villa Pia P Erbayraktar Zübeyde Z Gökmen Necati N Yilmaz Osman O Erbayraktar Serhat S Manohasandra Mathini M Van Hummelen Paul P Vandenabeele Peter P Chernajovsky Yuti Y Annenkov Alexander A Ghezzi Pietro P

Proceedings of the National Academy of Sciences of the United States of America 20120529 24

Erythropoietin (EPO) is a neuroprotective cytokine in models of ischemic and nervous system injury, where it reduces neuronal apoptosis and inflammatory cytokines and increases neurogenesis and angiogenesis. EPO also improves cognition in healthy volunteers and schizophrenic patients. We studied the effect of EPO administration on the gene-expression profile in the ischemic cortex of rats after cerebral ischemia at early time points (2 and 6 h). EPO treatment up-regulated genes already increased ...[more]

PMID: 22645329

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Dataset Information

Effect of erythropoietin on cerebral ischemia-induced changes in gene expression in rats

Publications

Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke.

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