Unknown,Transcriptomics,Genomics,Proteomics

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Individual multidrug resistance patterns in AML patients point to the need for personalized molecular analysis


ABSTRACT: In this unique study, based on paired samples obtained at AML diagnosis and at relapse, we assessed 380 multidrug-resistance-related genes, using TaqMan-based qRT-PCR, as indicated by reports published over the past three decades. 11 paired AML samples taken at diagnosis and at relapse after treatment. Each patients act as its own control.

ORGANISM(S): Homo sapiens

SUBMITTER: jean-pierre gillet 

PROVIDER: E-GEOD-33787 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Background</h4>Studies of mechanisms mediating resistance to chemotherapy led to the discovery of the multidrug transporter ABCB1 (ATP-binding cassette, subfamily B, member 1), often expressed in leukemic cells of patients with acute myeloid leukemia (AML). Most clinical trials evaluating the strategy of inhibiting efflux-mediated chemotherapeutic resistance have been unsuccessful, clearly indicating the need for a better approach.<h4>Methods</h4>This study investigated the clinical relevanc  ...[more]

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