Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: jean-pierre gillet
PROVIDER: E-GEOD-33787 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Patel Chirayu C Stenke Leif L Varma Sudhir S Lindberg Marita Lagergren ML Björkholm Magnus M Sjöberg Jan J Viktorsson Kristina K Lewensohn Rolf R Landgren Ola O Gottesman Michael M MM Gillet Jean-Pierre JP
Cancer 20130514 16
<h4>Background</h4>Studies of mechanisms mediating resistance to chemotherapy led to the discovery of the multidrug transporter ABCB1 (ATP-binding cassette, subfamily B, member 1), often expressed in leukemic cells of patients with acute myeloid leukemia (AML). Most clinical trials evaluating the strategy of inhibiting efflux-mediated chemotherapeutic resistance have been unsuccessful, clearly indicating the need for a better approach.<h4>Methods</h4>This study investigated the clinical relevanc ...[more]