Genome wide localization of CTCF in activated mouse B cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Wolfgang Resch
PROVIDER: E-GEOD-33819 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes.
Yamane Arito A Resch Wolfgang W Kuo Nan N Kuchen Stefan S Li Zhiyu Z Sun Hong-wei HW Robbiani Davide F DF McBride Kevin K Nussenzweig Michel C MC Casellas Rafael R
Nature immunology 20101128 1
The cytidine deaminase AID hypermutates immunoglobulin genes but can also target oncogenes, leading to tumorigenesis. The extent of AID's promiscuity and its predilection for immunoglobulin genes are unknown. We report here that AID interacted broadly with promoter-proximal sequences associated with stalled polymerases and chromatin-activating marks. In contrast, genomic occupancy of replication protein A (RPA), an AID cofactor, was restricted to immunoglobulin genes. The recruitment of RPA to t ...[more]
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