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Role of Adenosine 2A Receptors (A2AR) on regulatory T cells (Tregs)

ABSTRACT: The adenosine 2A receptor (A2AR) is expressed on regulatory T cells (Tregs), but the functional significance is currently unknown. We compared the gene expression between wild-type (WT) and A2AR knockout (KO) Tregs and between WT Tregs treated with vehicle or a selective A2AR agonist. FACS-sorted GFP positive Tregs from WT or A2AR KO FoxP3GFP mouse spleen and lymph nodes were incubated 18 hr with vehicle (DMSO), a separate set of WT Tregs were incubated with the selective A2AR agonist ATL1222 10 nM (Dogwood Pharmaceuticals, Inc.) for 18 hr prior to RNA isolation.

ORGANISM(S): Mus musculus

SUBMITTER: Gilbert Kinsey

PROVIDER: E-GEOD-34006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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