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Epigenome analysis of saliva samples from alcohol users

ABSTRACT: Genome wide DNA methylation profiling of saliva DNA from 197 alcohol dependent subjects. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in saliva samples. Bisulphite converted DNA were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

ORGANISM(S): Homo sapiens

SUBMITTER: Jingyu Liu 

PROVIDER: E-GEOD-34035 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A study of the influence of sex on genome wide methylation.

Liu Jingyu J   Morgan Marilee M   Hutchison Kent K   Calhoun Vince D VD  

PloS one 20100406 4

Sex differences in methylation status have been observed in specific gene-disease studies and healthy methylation variation studies, but little work has been done to study the impact of sex on methylation at the genome wide locus-to-locus level or to determine methods for accounting for sex in genomic association studies. In this study we investigate the genomic sex effect on saliva DNA methylation of 197 subjects (54 females) using 20,493 CpG sites. Three methods, two-sample T-test, principle c  ...[more]

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