Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Nucleosome dynamics specifies genome-wide binding of the male germ cell gene regulator CTCFL and of CTCF

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE34091: Nucleosome dynamics specifies genome-wide binding of the male germ cell gene regulator CTCFL and of CTCF [Mouse430_2 Expression] GSE34092: Nucleosome dynamics specifies genome-wide binding of the male germ cell gene regulator CTCFL and of CTCF [MoGene-1_0 Expression] GSE34094: Nucleosome dynamics specifies genome-wide binding of the male germ cell gene regulator CTCFL and of CTCF [ChIP-Seq] Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: frank sleutels

PROVIDER: E-GEOD-34093 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner.

Sleutels Frank F Soochit Widia W Bartkuhn Marek M Heath Helen H Dienstbach Sven S Bergmaier Philipp P Franke Vedran V Rosa-Garrido Manuel M van de Nobelen Suzanne S Caesar Lisa L van der Reijden Michael M Bryne Jan Christian JC van Ijcken Wilfred W Grootegoed J Anton JA Delgado M Dolores MD Lenhard Boris B Renkawitz Rainer R Grosveld Frank F Galjart Niels N

Epigenetics & chromatin 20120618 1

<h4>Background</h4>CTCF is a highly conserved and essential zinc finger protein expressed in virtually all cell types. In conjunction with cohesin, it organizes chromatin into loops, thereby regulating gene expression and epigenetic events. The function of CTCFL or BORIS, the testis-specific paralog of CTCF, is less clear.<h4>Results</h4>Using immunohistochemistry on testis sections and fluorescence-based microscopy on intact live seminiferous tubules, we show that CTCFL is only transiently pres ...[more]

PMID: 22709888

Dataset Information

Nucleosome dynamics specifies genome-wide binding of the male germ cell gene regulator CTCFL and of CTCF

Publications

The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner.

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