Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): idiopathic myelofibrosis
SUBMITTER: Rossella Manfredini
PROVIDER: E-GEOD-3410 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Guglielmelli Paola P Zini Roberta R Bogani Costanza C Salati Simona S Pancrazzi Alessandro A Bianchi Elisa E Mannelli Francesco F Ferrari Sergio S Le Bousse-Kerdilès Marie-Caroline MC Bosi Alberto A Barosi Giovanni G Migliaccio Anna Rita AR Manfredini Rossella R Vannucchi Alessandro M AM
Stem cells (Dayton, Ohio) 20060921 1
This study was aimed at the characterization of a gene expression signature of the pluripotent hematopoietic CD34(+) stem cell in idiopathic myelofibrosis (IM), which would eventually provide novel pathogenetic insights and/or diagnostic/prognostic information. Aberrantly regulated genes were revealed by transcriptome comparative microarray analysis of normal and IM CD34(+) cells; selected genes were also assayed in granulocytes. One-hundred seventy four differentially expressed genes were ident ...[more]