Dataset Information
Genome wide analysis of macrophage gene expression after L. monocytogenes infection
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andrea Nino Castro
PROVIDER: E-GEOD-34103 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Lack of PPARγ in myeloid cells confers resistance to Listeria monocytogenes infection.
PloS one 20120521 5
The peroxisomal proliferator-activated receptor γ (PPARγ) is a nuclear receptor that controls inflammation and immunity. Innate immune defense against bacterial infection appears to be compromised by PPARγ. The relevance of PPARγ in myeloid cells, that organize anti-bacterial immunity, for the outcome of immune responses against intracellular bacteria such as Listeria monocytogenes in vivo is unknown. We found that Listeria monocytogenes infection of macrophages rapidly led to increased expressi ...[more]
