Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: chunjiang he
PROVIDER: E-GEOD-34185 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Zejuan Z Huang Hao H Chen Ping P He Miao M Li Yuanyuan Y Arnovitz Stephen S Jiang Xi X He Chunjiang C Hyjek Elizabeth E Zhang Jun J Zhang Zhiyu Z Elkahloun Abdel A Cao Donglin D Shen Chen C Wunderlich Mark M Wang Yungui Y Neilly Mary Beth MB Jin Jie J Wei Minjie M Lu Jun J Valk Peter J M PJM Delwel Ruud R Lowenberg Bob B Le Beau Michelle M MM Vardiman James J Mulloy James C JC Zeleznik-Le Nancy J NJ Liu Paul P PP Zhang Jiwang J Chen Jianjun J
Nature communications 20120221
HOXA9 and MEIS1 have essential oncogenic roles in mixed lineage leukaemia (MLL)-rearranged leukaemia. Here we show that they are direct targets of miRNA-196b, a microRNA (miRNA) located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukaemic cells. Forced expression of miR-196b significantly delays MLL-fusion-mediated leukemogenesis in primary bone marrow transplantation through suppressing Hoxa9/Meis1 expression. However, ectopic expression of miR-196b results in more aggressive le ...[more]