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Non-Overlapping Functions of the Polycomb group Cbx Family of Proteins in Embryonic Stem Cells

ABSTRACT: Gene expression profile in control and Cbx7 depleted (shRNA#33) mouse embryonic stem cells and embryoid bodies at day 9 4 samples, each one contains four biological replicas, except for ES-shCtr which contains 3 replicas

ORGANISM(S): Mus musculus

SUBMITTER: Luciano Di Croce

PROVIDER: E-GEOD-34191 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells.

Morey Lluis L Pascual Gloria G Cozzuto Luca L Roma Guglielmo G Wutz Anton A Benitah Salvador Aznar SA Di Croce Luciano L

Cell stem cell 20120101 1

Polycomb group proteins are essential regulators of cell fate decisions during embryogenesis. In mammals, at least five different Cbx proteins (Cbx2, Cbx4, Cbx6, Cbx7, and Cbx8) are known to associate with the core Polycomb repressive complex 1 (PRC1). Here we show that pluripotency and differentiation of mouse embryonic stem cells (ESCs) is regulated by different Cbx-associated PRC1 complexes with unique functions. Maintenance of pluripotency primarily depends on Cbx7, while lineage commitment ...[more]

PMID: 22226355

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