Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat embryo ductus arteriosis after maternal vitamin A administration


ABSTRACT: The effects of retinoic acid/vitamin A signal on the transcriptional profile of the ductus arteriosus during development were examined. Experiment Overall Design: Total RNA samples were isolated from pooled tissues obtained from Wister rat embryos on embryonic day 19 and 21, and from neonates on the day of birth (n>=120). The RNA was converted to biotin-labeled cRNA, which was hybridized to Affymetrix RG_U34A microarray. The hybridization experiments were performed in duplicate.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Yoji Sato 

PROVIDER: E-GEOD-3420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Maternal vitamin A alters gene profiles and structural maturation of the rat ductus arteriosus.

Yokoyama Utako U   Sato Yoji Y   Akaike Toru T   Ishida Seiichi S   Sawada Junichi J   Nagao Taku T   Quan Hong H   Jin Meihua M   Iwamoto Mari M   Yokota Shumpei S   Ishikawa Yoshihiro Y   Minamisawa Susumu S  

Physiological genomics 20070717 1


Retinoic acid (RA), a metabolite of vitamin A, has been proposed to regulate vascular remodeling and reactivity of the ductus arteriosus (DA). Using rat Affymetrix GeneChips, we found that a considerable number of genes in DA varied their expression levels in accordance with developmental mode: namely, preterm-, term-, and postnatal-dominant clusters. Among a total of 8,740 probe sets, maternal vitamin A administration (MVA) changed the expression levels of 91 genes (116 probe sets) >2.5-fold. A  ...[more]

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