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Pfizer Molecular Profile Data for Cell Lines

ABSTRACT: Baseline gene expression for cell lines growing in culture were measured by Affymetrix U133Plus2 arrays. Copy Number Variation for selected cell lines was also measured. Baseline gene expression for cell lines growing in culture were measured by Affymetrix U133Plus2 arrays. Three different sources of arrays were combined. Arrays were from Pfizer, Wyeth Breast Panel, and Wyeth NCI50 subset of NCI60 cell lines. CNV was determined by Affymetrix SNP6.0 arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Keith Ching 

PROVIDER: E-GEOD-34211 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735.

Hook Kenneth E KE   Garza Scott J SJ   Lira Maruja E ME   Ching Keith A KA   Lee Nathan V NV   Cao Joan J   Yuan Jing J   Ye Jingjing J   Ozeck Mark M   Shi Stephanie T ST   Zheng Xianxian X   Rejto Paul A PA   Kan Julie L C JL   Christensen James G JG   Pavlicek Adam A  

Molecular cancer therapeutics 20120105 3

PF-03814735 is a novel, reversible inhibitor of Aurora kinases A and B that finished a phase I clinical trial for the treatment of advanced solid tumors. To find predictive biomarkers of drug sensitivity, we screened a diverse panel of 87 cancer cell lines for growth inhibition upon PF-03814735 treatment. Small cell lung cancer (SCLC) and, to a lesser extent, colon cancer lines were very sensitive to PF-03814735. The status of the Myc gene family and retinoblastoma pathway members significantly  ...[more]

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