Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcriptional Alterations in Skeletal Muscle Following Desmin Deletion


ABSTRACT: Desmin is a cytoskeletal protein in muscle involved in integrating cellular space and transmitting forces. In this study we sought to determine the effects of desmin deletion on skeletal muscle at the transcriptional level across many pathways of muscle physiology. RNA was isolated from the TA muscle of mice of two genotypes (wildtype (WT) and desmin knockout (KO)) and two ages (7-9 weeks (Adult) and 12-14 months (Aged)). Numbers per group are as follows: WT_Adult (5), WT_Aged (5), KO_Adult (5), KO_Aged (4).

ORGANISM(S): Mus musculus

SUBMITTER: Gretchen Meyer 

PROVIDER: E-GEOD-34388 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Skeletal muscle fibrosis develops in response to desmin deletion.

Meyer Gretchen A GA   Lieber Richard L RL  

American journal of physiology. Cell physiology 20120321 11


Skeletal muscle is a dynamic composite of proteins that responds to both internal and external cues to facilitate muscle adaptation. In cases of disease or altered use, these messages can be distorted resulting in myopathic conditions such as fibrosis. In this work, we describe a mild and progressive fibrotic adaptation in skeletal muscle lacking the cytoskeletal intermediate filament protein desmin. Muscles lacking desmin become progressively stiffer, accumulate increased collagen, and increase  ...[more]

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