Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Gretchen Meyer
PROVIDER: E-GEOD-34388 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Meyer Gretchen A GA Lieber Richard L RL
American journal of physiology. Cell physiology 20120321 11
Skeletal muscle is a dynamic composite of proteins that responds to both internal and external cues to facilitate muscle adaptation. In cases of disease or altered use, these messages can be distorted resulting in myopathic conditions such as fibrosis. In this work, we describe a mild and progressive fibrotic adaptation in skeletal muscle lacking the cytoskeletal intermediate filament protein desmin. Muscles lacking desmin become progressively stiffer, accumulate increased collagen, and increase ...[more]