Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Stephen Desiderio
PROVIDER: E-GEOD-34421 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cooper Christopher L CL Hardy Richard R RR Reth Michael M Desiderio Stephen S
Blood 20120418 23
The role of hedgehog (Hh) signaling in B lymphopoiesis has remained unclear. We observed that the proliferation of pro-B cells in stromal cocultures was impaired by interruption of Hh signaling, prompting us to investigate whether the target of Hh antagonism was intrinsic or extrinsic to the B-lymphoid compartment. In the present study, using conditional deletion of the pathway activator gene Smo, we found that cell-autonomous Hh signaling is dispensable for B-cell development, B-lymphoid repopu ...[more]