Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Arne Mueller
PROVIDER: E-GEOD-34463 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lempiäinen Harri H Müller Arne A Brasa Sarah S Teo Soon-Siong SS Roloff Tim-Christoph TC Morawiec Laurent L Zamurovic Natasa N Vicart Axel A Funhoff Enrico E Couttet Philippe P Schübeler Dirk D Grenet Olivier O Marlowe Jennifer J Moggs Jonathan J Terranova Rémi R
PloS one 20110324 3
Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histone modifications) may take place at the earliest stages of carcinogenesis and their identification holds great promise for biomedical research. Here, we evaluate the sensitivity and specificity of genome-wide epigenomic and transcriptomic profiling in ...[more]