Focal chromosomal aberrations in high-grade cervical intraepithelial neoplasia reveal hsa-miR-375 and EYA2 as drivers in HPV-mediated transformation

ABSTRACT: Cervical cancer results from the accumulation of (epi)genetic aberrations following persistent infection with high-risk human papillomavirus (HPV). In order to define genetic aberrations associated with cervical carcinogenesis, chromosomal profiles of high-grade cervical intraepithelial neoplasia (CIN) were generated. Common aberrations usually encompass large genomic regions and contain numerous genes, hampering identification of actual driver genes. Consequently, direct evidence of chromosomal alterations actively contributing to cervical carcinogenesis has been lacking so far. By analyzing 60 high-grade CIN with high resolution arrayCGH we identified focal chromosomal aberrations that each harbour only one or a few genes. In total 74 focal aberrations were identified encoding 305 genes

ORGANISM(S): Homo sapiens

SUBMITTER: Oscar Krijgsman 

PROVIDER: E-GEOD-34575 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress